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Label: World
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Label: Technology
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Study: Stem cells from strangers can repair hearts
Label: HealthLOS ANGELES (AP) — Researchers are reporting a key advance in using stem cells to repair hearts damaged by heart attacks. In a study, stem cells donated by strangers proved as safe and effective as patients' own cells for helping restore heart tissue.
The work involved just 30 patients in Miami and Baltimore, but it proves the concept that anyone's cells can be used to treat such cases. Doctors are excited because this suggests that stem cells could be banked for off-the-shelf use after heart attacks, just as blood is kept on hand now.
Results were discussed Monday at an American Heart Association conference in California and published in the Journal of the American Medical Association.
The study used a specific type of stem cells from bone marrow that researchers believed would not be rejected by recipients. Unlike other cells, these lack a key feature on their surface that makes the immune system see them as foreign tissue and attack them, explained the study's leader, Dr. Joshua Hare of the University of Miami.
The patients in the study had suffered heart attacks years earlier, some as long as 30 years ago. All had developed heart failure because the scar tissue from the heart attack had weakened their hearts so much that they grew large and flabby, unable to pump blood effectively.
Researchers advertised for people to supply marrow, which is removed using a needle into a hip bone. The cells were taken from the marrow and amplified for about a month in a lab at Baltimore's Johns Hopkins University, then returned to Miami to be used for treatment, which did not involve surgery.
The cells were delivered through a tube pushed through a groin artery into the heart near the scarred area. Fifteen patients were given cells from their own marrow and 15 others, cells from strangers.
About a year later, scar tissue had been reduced by about one-third. Both groups had improvements in how far they could walk and in quality of life. There was no significant difference in one measure of how well their hearts were able to pump blood, but doctors hope these patients will continue to improve over time, or that refinements in treatment will lead to better results.
The big attraction is being able to use cells supplied by others, with no blood or tissue matching needed.
"You could have the cells ready to go in the blood bank so when the patient comes in for a therapy — there's no delay," Hare said. "It's also cheaper to make the donor cells," and a single marrow donor can supply enough cells to treat as many as 10 people.
Dr. Elliott Antman of Harvard-affiliated Brigham and Women's Hospital in Boston who heads the heart conference, praised the work.
"That opens up an entire new avenue for stem cell therapy, like a sophisticated version of a blood bank," he said. There's an advantage in not having to create a cell therapy for each patient, and it could spare them the pain and wait of having their own marrow harvested, he said.
The study was sponsored by the National Institutes of Health. Hare owns stock in a biotech company working on a treatment using a mixture of cells.
Juan Lopez received his own cells in the study, and said it improved his symptoms so much that at age 70, he was able to return to his job as an engineer and sales manager for a roofing manufacturer and ride an exercise bike.
"It has been a life-changing experience," said Lopez, who lives in Miami. "I can feel day by day, week by week, month by month, my improvement. I don't have any shortness of breath and my energy level is way up there. I don't have any fluid in my lungs."
And, he said happily, "My sex drive has improved!"
___
Marilynn Marchione can be followed at http://twitter.com/MMarchioneAP .
Race for the White House: Join us live
Label: Business
Elephant in South Korean zoo imitates human speech
Label: WorldSEOUL, South Korea (AP) — An elephant in a South Korean zoo is using his trunk to pick up not only food, but also human vocabulary.
An international team of scientists confirmed Friday what the Everland Zoo has been saying for years: Their 5.5-ton tusker Koshik has an unusual and possibly unprecedented talent.
The 22-year-old Asian elephant can reproduce five Korean words by tucking his trunk inside his mouth to modulate sound, the scientists said in a joint paper published online in Current Biology. They said he may have started imitating human speech because he was lonely.
Koshik can reproduce "annyeong" (hello), "anja" (sit down), "aniya" (no), "nuwo" (lie down) and "joa" (good), the paper says.
One of the researchers said there is no conclusive evidence that Koshik understands the sounds he makes, although the elephant does respond to words like "anja."
Everland Zoo officials in the city of Yongin said Koshik also can imitate "ajik" (not yet), but the researchers haven't confirmed the accomplishment.
Koshik is particularly good with vowels, with a rate of similarity of 67 percent, the researchers said. For consonants he scores only 21 percent.
Researchers said the clearest scientific evidence that Koshik is deliberately imitating human speech is that the sound frequency of his words matches that of his trainers.
Vocal imitation of other species has been found in mockingbirds, parrots and mynahs. But the paper says Koshik's case represents "a wholly novel method of vocal production" because he uses his trunk to reproduce human speech.
In 1983, zoo officials in Kazakhstan reportedly claimed that a teenage elephant named Batyr could reproduce Russian to utter 20 phrases, including "Batyr is good." But there was no scientific study on the claim.
Researchers believe Koshik learned to reproduce words out of a desire to bond with his trainers after he was separated from two other elephants at age 5.
Koshik emerged as a star among animal enthusiasts and children in South Korea after Everland Zoo claimed in 2006 that he could imitate words, two years after his trainers noticed the phenomenon. His growing reputation prompted Austrian biologist Angela Stoeger-Horwath and German biophysicist Daniel Mietchen to study him in 2010, zoo officials said.
Oh Suk-hun, a South Korean veterinarian who co-authored the research paper with Stoeger-Horwath and Mietchen, said the elephant apparently started imitating human speech to win the trust of his trainers.
In April, a children's science book called "Joa Joa, Speaking Elephant" was published. The cover photo showed Koshik opening his mouth wide while raising a trunk over his trainer's head.
Researchers said Koshik was trained to obey several commands and "exposed to human speech intensively" by trainers, veterinarians and zoo visitors.
Shin Nam-sik, a veterinary professor at Seoul National University who has seen Koshik, agreed with researchers' finding that the elephant was able to mimic human speech.
"In Koshik's case, the level of intimacy between him and his trainer was the key factor that made the elephant want to sound like a human," Shin said.
Kim Jong-gab, Koshik's chief trainer, said the elephant was timid for a male when he first came to Everland Zoo, so trainers often slept in the same area with him. Kim thinks that contact helped Koshik feel closer to humans.
Kim said he has another phrase he wants to teach Koshik: "Saranghae," or "I love you."
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